Sickle Cell

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Submitted By joetownhound
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Sickle Cell Anemia
Dennis Martin
Jersey College School of Nursing
Pediatric Nursing
Ms. Fran Davis
September 30, 2013

Sickle cell disease (SCD) is a multisystem disease, associated with episodes of acute illness and progressive organ damage, and is one of the most common severe monogenic disorders worldwide. Understand of the disease has gradually increased since the disease was first described with a characteristic sickle shaped erythrocytes by Herrick in 1910 (Herrick, 1910). This literature will cover what is SCD, along with other topic such as pathophysiology, etiology, sign and symptoms, risk factors and patient teaching.
Sickle Cell Anemia
Sickle cell disease (SCD) is a multisystem disease, associated with episodes of acute illness and progressive organ damage, and is one of the most common severe monogenic disorders worldwide (Weatherall, Hofman, Rodgers, Ruffin, & Hrynkow, 2004). Understand of the disease has gradually increased since the disease was first described with a characteristic sickle shaped erythrocytes by Herrick in 1910 (Herrick, 1910). In 1951 A Nobel Prize-Prize winning chemist by the name of Dr. Linus Pauling and his colleague Dr. Harvey Itano, discovered that the red, oxygen carrying protein called "hemoglobin" had a different chemical structure in persons with SCD. This led Dr. Pauling to coin the term "molecular disease" for disorders that resulted from proteins and abnormal chemical structures (Winter, n.d.). Although thousands of such diseases are known, SCD was the first to be studied with details of the abnormality worked out by Dr. Vernon Ingram in 1956 (Winter, n.d.). It wasn't until the 1970's before more details of how this abnormal structure affected the red bloods cell of people with SCD. In the years that followed, technology and better tests for the detection of the SCD was developed. This…...

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